P113 (Oral Care Peptide)

P113 is a next-generation antimicrobial peptide (AMP) inspired by naturally occurring peptides found in the oral environment. It is widely used in oral-care formulation development as a functional active to support freshness, a clean-mouth feel, and overall oral environment balance. P113 can be incorporated into multiple product formats—including toothpaste, mouthwash, oral sprays, and gels—and is well suited for brands looking to build modern, science-forward oral-care concepts.

Quality support: RM Biotech provides high-quality P113 with COA, and identity/purity verification (e.g., HPLC, MS), plus recommended storage and handling guidance.

What is P-113?
Definition: P-113 is a 12-amino-acid engineered antimicrobial peptide derived from the human salivary peptide Histatin-5 (Hst5)—capturing Hst5’s minimal active core.
Typical sequence: Canonical literature sequence is AKRHHGYKRKFH.Your working sequence AKRHHGYKRKFH is a terminally modified variant commonly used for formulation stability/compatibility.

Why P-113 Matters
Clear human origin (salivary peptide lineage) → supportive safety rationale.
Manufacturability: Short length (12 aa) enables reliable HPLC/MS release and batch consistency.
Functional positioning: Broad Candida activity with additional Gram± coverage and anti-biofilm potential—fit for oral/skin hygiene positioning.
Engineerable: End-group tuning, D-substitutions, multimerization, lipidation, and carrier systems allow balancing stability, persistence, and spectrum.